A CoD-based reduction algorithm for designing stationary control policies on Boolean networks
نویسندگان
چکیده
منابع مشابه
A CoD-based reduction algorithm for designing stationary control policies on Boolean networks
MOTIVATION Gene regulatory networks serve as models from which to derive therapeutic intervention strategies, in particular, stationary control policies over time that shift the probability mass of the steady state distribution (SSD) away from states associated with undesirable phenotypes. Derivation of control policies is hindered by the high-dimensional state spaces associated with gene regul...
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The current paper uses a 17-gene real-world derived network for comparing the performance of the CoD-CP with MFPT-CP and SSD-CP. The CoD-CP can be used for directly designing the stationary control policy on the 17-gene network and only need the SSD of the network. To compare the performance of the CoD-CP designed on the 17-gene network with the MFPT-CP and SSD-CP, we had to reduce the size of ...
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ژورنال
عنوان ژورنال: Bioinformatics
سال: 2010
ISSN: 1460-2059,1367-4803
DOI: 10.1093/bioinformatics/btq225